Top Drugs: Top Synthetic Routes (Oxford Chemistry Primers)

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9780198501008: Top Drugs: Top Synthetic Routes (Oxford Chemistry Primers)

Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis.

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About the Author:

Dr John Saunders, Neurocrine Biosciences, 10555 Science Center Drive, San Diego, CA 92121, USA.

Review:


"This is a good introduction to the synthetic chemistry required to fuel the pharmaceutical industry and should encourage students to pursue a career in this exciting field." -- Doody's


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1.

John Saunders
Editorial: Oxford University Press, United Kingdom (2012)
ISBN 10: 0198501005 ISBN 13: 9780198501008
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Descripción Oxford University Press, United Kingdom, 2012. Paperback. Estado de conservación: New. Language: English . Brand New Book. Today s top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis. Nº de ref. de la librería AAU9780198501008

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John Saunders
Editorial: OUP Oxford 2000-05-18, Oxford (2000)
ISBN 10: 0198501005 ISBN 13: 9780198501008
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Descripción OUP Oxford 2000-05-18, Oxford, 2000. paperback. Estado de conservación: New. Nº de ref. de la librería 9780198501008

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John Saunders
Editorial: Oxford University Press, United Kingdom (2012)
ISBN 10: 0198501005 ISBN 13: 9780198501008
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Descripción Oxford University Press, United Kingdom, 2012. Paperback. Estado de conservación: New. Language: English . Brand New Book. Today s top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis. Nº de ref. de la librería AAU9780198501008

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John Saunders
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Descripción Oxford University Press. Paperback. Estado de conservación: new. BRAND NEW, Top Drugs: Top Synthetic Routes, John Saunders, Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis. Nº de ref. de la librería B9780198501008

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Saunders, John
Editorial: Oxford University Press (2012)
ISBN 10: 0198501005 ISBN 13: 9780198501008
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Descripción Oxford University Press, 2012. Estado de conservación: New. This title allows students to see how the organic chemistry taught in undergraduate courses is applied by medicinal chemists in industry. This book describes briefly how each drug works and then reviews the most efficient routes to their synthesis. Series: Oxford Chemistry Primers. Num Pages: 96 pages, numerous line illustrations. BIC Classification: PN; TDCW. Category: (U) Tertiary Education (US: College). Dimension: 245 x 189 x 6. Weight in Grams: 198. . 2012. 1st Edition. Paperback. . . . . . Nº de ref. de la librería V9780198501008

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Saunders, John
Editorial: Oxford University Press
ISBN 10: 0198501005 ISBN 13: 9780198501008
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Descripción Oxford University Press. Estado de conservación: New. This title allows students to see how the organic chemistry taught in undergraduate courses is applied by medicinal chemists in industry. This book describes briefly how each drug works and then reviews the most efficient routes to their synthesis. Series: Oxford Chemistry Primers. Num Pages: 96 pages, numerous line illustrations. BIC Classification: PN; TDCW. Category: (U) Tertiary Education (US: College). Dimension: 245 x 189 x 6. Weight in Grams: 198. . 2012. 1st Edition. Paperback. . . . . Books ship from the US and Ireland. Nº de ref. de la librería V9780198501008

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John Saunders
Editorial: Oxford University Press, USA (2000)
ISBN 10: 0198501005 ISBN 13: 9780198501008
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Ria Christie Collections
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Descripción Oxford University Press, USA, 2000. Estado de conservación: New. book. Nº de ref. de la librería ria9780198501008_rkm

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Descripción Oxford University Press. Estado de conservación: Brand New. Ships from USA. FREE domestic shipping. Nº de ref. de la librería 0198501005

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Saunders, John
Editorial: OUP Oxford (2000)
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Descripción OUP Oxford, 2000. PAP. Estado de conservación: New. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Nº de ref. de la librería BB-9780198501008

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John Saunders
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ISBN 10: 0198501005 ISBN 13: 9780198501008
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Descripción OUP Oxford, 2000. Estado de conservación: New. Nº de ref. de la librería EH9780198501008

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