The Compass of Pleasure: How Our Brains Make Fatty Foods, Orgasm, Exercise, Marijuana, Generosity, Vodka, Learning, and Gambling Feel So Good

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9780143120759: The Compass of Pleasure: How Our Brains Make Fatty Foods, Orgasm, Exercise, Marijuana, Generosity, Vodka, Learning, and Gambling Feel So Good

From the New York Times bestselling author comes a "hugely entertaining" (NPR.org) look at vice and virtue through cutting-edge science

As he did in his award-winning book The Accidental Mind, David J. Linden—highly regarded neuroscientist, professor, and writer—weaves empirical science with entertaining anecdotes to explain how the gamut of behaviors that give us a buzz actually operates. The Compass of Pleasure makes clear why drugs like nicotine and heroin are addictive while LSD is not, how fast food restaurants ensure that diners will eat more, why some people cannot resist the appeal of a new sexual encounter, and much more. Provocative and illuminating, this is a radically new and thorough look at the desires that define us.

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About the Author:

David J. Linden is a professor of neuroscience at the Johns Hopkins University School of Medicine. The author of The Accidental Mind—winner of a Silver Medal at the Independent Publisher's Book Awards—he serves as the editor in chief of the Journal of Neurophysiology. He lives in Baltimore, Maryland.

Excerpt. © Reprinted by permission. All rights reserved.:

Praise for The Compass of Pleasure

 

“In his book The Compass of Pleasure, the Johns Hopkins neurobiologist David J. Linden explicates the workings of [the regions of the brain] known collectively as the reward system, elegantly drawing on sources ranging from personal experience to studies of brain activity to experiments with molecules and genes.”

The New York Times Book Review

“Important, timely, and fascinating.”

—Naomi Wolf, author of The Shock Doctrine, The Beauty Myth, and The End of America

“[H]ugely entertaining . . . If you’re science-phobic, don’t worry: Linden is incredibly smart, but comes across as the funny, patient professor you wish you’d had in college.”

—www.npr.org

“How do orgasms, heroin, greasy foods, and juicy gossip jolt the same neurons? Neuroscientist David Linden delves into the research, mixing in plenty of trippy anecdotes.”

Psychology Today

“Linden’s conversational style, his abundant use of anecdotes, and his successful coupling of wit with insight makes the book a joy to read. Even the footnotes are sprinkled with hidden gems.”

Publishers Weekly

“Conventional wisdom advises, “If it feels good, stop it. If it tastes good, spit it out.” But why? Because indulging pleasurable excess, whether of drugs, food, or sex, has an unforgiving downside. The biology of how we know this is the topic of Linden’s fascinating, by turns technical and entertaining effort.”

—Donna Chavez, Booklist

“This cheerful summary of the brain’s reward system is a profound experience. . . . Pleasure is a superb book. My brain has been changed by reading it.”

—Leo Benedictus, The Guardian (London)

“This book is highly readable and full of fascinating facts and theories. . . . You’re sure to get pleasure from reading Pleasure.”

—Susan Blackmore, BBC Focus (London)

ABOUT THE AUTHOR

 

David J. Linden is a professor of neuroscience at The Johns Hopkins University School of Medicine. The author of The Accidental Mind (2007), The Compass of Pleasure (2011), and most recently, Touch (2015), he served for many years as the chief editor of The Journal of Neurophysiology. He lives in Baltimore, Maryland, with his two children.

Praise for The Compass of Pleasure

About the Author

Title Page

Copyright

Dedication

Epigraph

Prologue

CHAPTER ONE Mashing the Pleasure Button

CHAPTER TWO Stoned Again

CHAPTER THREE Feed Me

CHAPTER FOUR Your Sexy Brain

CHAPTER FIVE Gambling and Other Modern Compulsions

CHAPTER SIX Virtuous Pleasures (and a Little Pain)

CHAPTER SEVEN The Future of Pleasure

Acknowledgments

Notes

Index

“Pleasure never comes sincere to man;

but lent by heaven upon hard usury.”

—John Dryden, Edippus

“Phil was probably passed out somewhere, enjoying his dead father’s legacy. I found myself wishing I had a loved one who would die and leave me their barbiturates, but I couldn’t think of anyone who’d ever loved me that much. My uncle had already promised his to the mail lady.”

—Donald Ray Pollock, “Bactine”

PROLOGUE

Bangkok, 1989. The afternoon rains have ended, leaving the early evening air briefly free of smog and allowing that distinctive Thai perfume, frangipani with a faint note of sewage, to waft over the shiny streets. I hail a tuk-tuk, a three-wheel motorcycle taxi, and hop aboard. My young driver has an entrepreneurial smile as he turns around and begins the usual interrogation of male travelers.

“So ...you want girl?”

“No.”

“I see.” Long pause, eyebrows slowly raised. “You want boy!”

“Uh, no.”

Longer pause. Sound of engine sputtering at idle. “You want ladyboy?”

“No,” I answer, a bit more emphatically, nonplussed at the idea that I give the impression of desiring this particular commodity.

“I got cheap cigarettes ...Johnnie Walker ...”

“No thanks.”

Undaunted, he moves on to the next category of his wares, now with lowered voice.

“You want ganja?”

“No.”

“Coke?”

“No.”

“Ya baa [methamphetamine tablets]?”

“Nope.”

A whisper now. “Heroin?”

“No.”

Voice raised back to normal. “I can take you to cockfight. You can gamble!”

“I’ll pass.”

Just a little bit irritated now. “So, farang, what you want?”

“Prik kee noo,” I respond. “Those little ‘mouse shit’ peppers. I want some good, spicy dinner.” My driver, not surprisingly, is disappointed. As we tear through the streets to a restaurant, blasting through puddles, I’m left wondering: Aside from various shades of illegality, what do all his offers have in common? What is it exactly that makes a vice?

 

We humans have a complicated and ambivalent relationship to pleasure, which we spend an enormous amount of time and resources pursuing. A key motivator of our lives, pleasure is central to learning, for we must find things like food, water, and sex rewarding in order to survive and pass our genetic material to the next generation. Certain forms of pleasure are accorded special status. Many of our most important rituals involving prayer, music, dance, and meditation produce a kind of transcendent pleasure that has become deeply ingrained in human cultural practice.

As we do with most powerful forces, however, we also want to regulate pleasure. In cultures around the world we find well-defined ideas and rules about pleasure that have persisted throughout history in any number of forms and variations:

Pleasure should be sought in moderation.

Pleasure must be earned.

Pleasure must be achieved naturally.

Pleasure is transitory.

The denial of pleasure can yield spiritual growth.

Our legal systems, our religions, our educational systems are all deeply concerned with controlling pleasure. We have created detailed rules and customs surrounding sex, drugs, food, alcohol, and even gambling. Jails are bursting with people who have violated laws that proscribe certain forms of pleasure or who profit by encouraging others to do so.

One can fashion reasonable theories of human pleasure and its regulation using the methods of cultural anthropology or social history. These are valid and useful endeavors, for ideas and practices involving human pleasure are certainly deeply influenced by culture. However, what I’m seeking here in The Compass of Pleasure is a different type of understanding—one less nuanced, perhaps, but more fundamental: a cross-cultural biological explanation. In this book I will argue that most experiences in our lives that we find transcendent—whether illicit vices or socially sanctioned ritual and social practices as diverse as exercise, meditative prayer, or even charitable giving—activate an anatomically and biochemically defined pleasure circuit in the brain. Shopping, orgasm, learning, highly caloric foods, gambling, prayer, dancing ’til you drop, and playing on the Internet: They all evoke neural signals that converge on a small group of interconnected brain areas called the medial forebrain pleasure circuit. It is in these tiny clumps of neurons that human pleasure is felt. This intrinsic pleasure circuitry can also be co-opted by artificial activators like cocaine or nicotine or heroin or alcohol. Evolution has, in effect, hardwired us to catch a pleasure buzz from a wide variety of experiences from crack to cannabis, from meditation to masturbation, from Bordeaux to beef.

This theory of pleasure reframes our understanding of the part of the human body that societies are most intent upon regulating. While we might assume that the anatomical region most closely governed by laws, religious prohibitions, and social mores is the genitalia, or the mouth, or the vocal cords, it is actually the medial forebrain pleasure circuit. As societies and as individuals, we are hell-bent on achieving and controlling pleasure, and it is those neurons, deep in our brains, that are the nexus of that struggle.

These particular neurons also comprise another battleground. The dark side of pleasure is, of course, addiction. It is now becoming clear that addiction is associated with long-lasting changes in the electrical, morphological, and biochemical functions of neurons and synaptic connections within the medial forebrain pleasure circuit. There are strong suggestions that these changes underlie many of the terrifying aspects of addiction, including tolerance (needing successively larger doses to get high), craving, withdrawal, and relapse. Provocatively, such persistent changes appear to be nearly identical to experience-and learning-driven changes in neural circuitry that are used to store memories in other brain regions. In this way, memory, pleasure, and addiction are closely intertwined.

However, addiction is not the only force responsible for experience-driven changes within the brain’s pleasure circuits. The combination of associative learning and pleasure has created nothing less than a cognitive miracle: We can be motivated by pleasure to achieve goals that are entirely arbitrary—goals that may or may not have an evolutionary adaptive value. These can be as wide-ranging as reality-based television and curling. For us humans (and probably for other primates and for cetaceans as well), even mere ideas can activate the pleasure circuit. Our eclecticism where pleasure is concerned serves to make our human existence wonderfully rich and complex.

 

I like to tell the students in my lab that the golden age of brain research is right now, so it’s time to get down to business. This sounds like a cheap motivational gimmick, but it’s true. Our accumulating understanding of neural function, coupled with enabling technologies that allow us to measure and manipulate the brain with unprecedented precision, has given us new and often counterintuitive insights into behavioral and cognitive phenomena  at the levels of biological processes. Nowhere is this more evident than in the neurobiology of pleasure. One example: Do you, like many, think that drug addicts become drug addicts because they derive greater reward from getting high than others? The biology says no: They actually seem to want it more but like it less.

This level of analysis is not only of academic interest. Understanding the biological basis of pleasure leads us to fundamentally rethink the moral and legal aspects of addiction to drugs, food, sex, and gambling and the industries that manipulate these pleasures in the marketplace. It also calls for a reformation in our concepts of such virtuous and prosocial behaviors as sharing resources, self-deprivation, and the drive for knowledge. Crucially, brain imaging studies show that giving to charity, paying taxes, and receiving information about future events all activate the same neural pleasure circuit that’s engaged by heroin or orgasm or fatty foods. Perhaps, most important, analysis of the molecular basis of enduring changes in the brain’s pleasure circuitry holds great promise for developing drugs and other therapies to help people break free of addictions of many sorts, to both substances and experiences.

When I was a postdoctoral fellow at the Roche Institute of Molecular Biology in the early 1990s, I was fortunate to work with Sid Udenfriend, a pioneer in the biochemistry of the brain and a real mensch. Sid’s favorite pedagogical phrase, usually intoned at the bar, was “It’s always good to know a little chemistry.” I couldn’t agree more. It would be possible to write a book exploring the brain’s pleasure circuits that was free of not only molecules but also basic anatomy, but that sort of spoon-feeding would require ignoring some of the most interesting and important issues, and so that’s not what you’ll find here. If you come along for the ride and work with me just a bit to learn some basic neuroscience, I’ll do my best to make it lively and fun as we explore the cellular and molecular basis of human pleasure, transcendent experience, and addiction.

CHAPTER ONE

MASHING THE PLEASURE BUTTON

Montréal, 1953. Fortunately, Peter Milner and James Olds didn’t have perfect aim. While postdoctoral fellows at McGill University, under the direction of the renowned psychologist Donald Hebb, Olds and Milner were conducting experiments that involved implanting electrodes deep in the brains of rats. The implanting surgery, conducted while the animals were anesthetized, involved cementing a pair of electrodes half a millimeter apart to their skulls. After a few days of recovery from the surgery, the rats were fine. Long, flexible wires were then attached to the electrodes at one end and to an electrical stimulator at the other, to allow for activation of the specific brain region where the tips of the electrodes had come to rest.

One fall day Olds and Milner were testing a rat in which they had attempted to target a structure called the midbrain reticular system. Located at the midline of the brain, at the point where its base tapers to form the brain stem, this region had previously been shown by another lab to control sleeping and waking cycles. In this particular surgery, however, the electrodes had gone astray and come to rest still at the midline, but at a somewhat more forward position in the brain, in a region called the septum.

The rat in question was placed in a large rectangular box with corners labeled A, B, C, and D and was allowed to explore freely. Whenever the rat went to corner A, Olds pressed a button that delivered a brief, mild electrical shock through the implanted electrodes. (Unlike the rest of the body, brain tissue does not have the receptors that allow for pain detection, so such shocks don’t produce a painful sensation within the skull.) After a few jolts, the rat kept returning to corner A and finally fell asleep in a different location. The next day, however, the rat seemed even more interested in corner A than the others. Olds and Milner were excited: They believed that they had found a brain region that, when stimulated, provoked general curiosity. However, further experiments on this same rat soon proved that not to be the case. By this time, the rat had acquired a habit of returning often to corner A to be stimulated. The researchers then tried to coax the rat away from corner A by administering a shock every time the rat made a step in the direction of corner B. This worked all too well—within five minutes, the rat relocated to corner B. Further investigation revealed that this rat could be directed to any location within the box with well-timed brain shocks—brief ones to guide the rat to the target lo...

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Descripción Penguin Books, United States, 2012. Paperback. Estado de conservación: New. Reprint. Language: English . Brand New Book. From the New York Times bestselling author comes a hugely entertaining ) look at vice and virtue through cutting-edge scienceAs he did in his award-winning book The Accidental Mind, David J. Linden highly regarded neuroscientist, professor, and writer weaves empirical science with entertaining anecdotes to explain how the gamut of behaviors that give us a buzz actually operates. The Compass of Pleasure makes clear why drugs like nicotine and heroin are addictive while LSD is not, how fast food restaurants ensure that diners will eat more, why some people cannot resist the appeal of a new sexual encounter, and much more. Provocative and illuminating, this is a radically new and thorough look at the desires that define us. Nº de ref. de la librería ABZ9780143120759

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