Natural Hosts of SIV: Implication in AIDS - Tapa dura

Acerca de los autores

Aftab Ansari, Ph.D.

Dr. Aftab A. Ansari, Professor, Department of Pathology and Laboratory Medicine, Room 2309 WMB, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA

Ph.D., University of Arizona, Tucson, Arizona, 1970

M.S., University of California, Los Angeles, CA, 1967

M.S., University of Karachi, Karachi, Pakistan, 1963

B.S., University of Karachi, Karachi, Pakistan, 1961

1981-present Senior Consultant, Naval Medical Research and Development Command, Bethesda, Maryland

1985-Present Professor, Department of Pathology and Laboratory Medicine, Emory University

1999-present Scientific Advisor, U.S. Naval Medical Research Unit #2, Jakarta, Indonesia.

2002-present Scientific Advisory Board, One World Health, San Francisco, CA.

2001-2008 Scientific Advisory Board, Lipid Sciences, Inc. Pleasanton, CA.

2005-present Scientific External Advisory Board member, CAHDR, Meharry Medical College,

Nashville, TN

2008-present Scientific Advisory Board, SMART Technologies, Inc., Rehovot, Israel

2007-present Member, FDA Expert Panel, FDA Center for Devices and Radiological Health

(CDRH), SGE, Deptt. Of Health & Human Services, Immunology Devices Panel

Chief, Division of Microbiology and Immunology, Yerkes National Primate Research Center

Georgia Research Alliance Eminent Scholar in Comparative Pathology, Emory University

De la contraportada

Natural Hosts of SIV: Implications in AIDS delivers a comprehensive review of the possible mechanism(s) by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free when other hosts exhibit disease and death, ultimately aiming to shed light on arenas for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.

Aiming to elucidate this captivating occurrence, Natural Hosts of SIV delivers a composite view of the virological, immunological, genetic and molecular aspects of virus-host relationships of SIV infection of natural hosts. Without an effective sterilizing vaccine again HIV-1, defining the methodologies by which an HIV-1 infected individual remain infected and disease-free, like the African nonhuman natural hosts of the simian immunodeficiency viruses (SIV), is particularly compelling. Understanding the potential mechanisms by which these natural hosts avoid disease development despite high viral loads could provide a road map for the formulation of an alternate vaccine strategy against HIV-1. This work makes important in-roads to enhance an understanding of whether the mechanisms at work in this scenario can be successfully exploited for therapeutic application in HIV-1 infected humans.

Key Features

• Summarizes the research conducted in this field for the past 30 years and describes the latest developments in AIDS research using nonhuman primate animal models • Provides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIV • Highlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection