The Gene: An Intimate History

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9780099584575: The Gene: An Intimate History

From the Pulitzer Prize-winning, bestselling author of The Emperor of All Maladies―a magnificent history of the gene and a response to the defining question of the future: What becomes of being human when we learn to “read” and “write” our own genetic information?

Siddhartha Mukherjee has a written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

Throughout the narrative, the story of Mukherjee’s own family―with its tragic and bewildering history of mental illness―cuts like a bright, red line, reminding us of the many questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In superb prose and with an instinct for the dramatic scene, he describes the centuries of research and experimentation―from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.

As The New Yorker said of The Emperor of All Maladies, “It’s hard to think of many books for a general audience that have rendered any area of modern science and technology with such intelligence, accessibility, and compassion...An extraordinary achievement.” Riveting, revelatory, and magisterial history of a scientific idea coming to life, and an essential preparation for the moral complexity introduced by our ability to create or “write” the human genome, The Gene is a must-read for everyone concerned about the definition and future of humanity. This is the most crucial science of our time, intimately explained by a master.

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Review:

An Amazon Best Book of May 2016: In 2010, Siddhartha Mukherjee was awarded the Pulitzer Prize for his book The Emperor of All Maladies, a “biography” of cancer. Here, he follows up with a biography of the gene—and The Gene is just as informative, wise, and well-written as that first book. Mukherjee opens with a survey of how the gene first came to be conceptualized and understood, taking us through the thoughts of Aristotle, Darwin, Mendel, Thomas Morgan, and others; he finishes the section with a look at the case of Carrie Buck (to whom the book is dedicated), who eventually was sterilized in 1927 in a famous American eugenics case. Carrie Buck’s sterilization comes as a warning that informs the rest of the book. This is what can happen when we start tinkering with this most personal science and misunderstand the ethical implications of those tinkerings. Through the rest of The Gene, Mukherjee clearly and skillfully illustrates how the science has grown so much more advanced and complicated since the 1920s—we are developing the capacity to directly manipulate the human genome—and how the ethical questions have also grown much more complicated. We could ask for no wiser, more fascinating and talented writer to guide us into the future of our human heredity than Siddhartha Mukherjee. --Chris Schluep

About the Author:

Siddhartha Mukherjee is a cancer physician and researcher. He is an assistant professor of medicine at Columbia University and a staff cancer physician at the CU/NYU Presbytarian Hospital. A former Rhodes scholar, he graduated from Stanford University, University of Oxford (where he received a PhD studying cancer-causing viruses) and from Harvard Medical School. His laboratory focuses on discovering new cancer drugs using innovative biological methods. Mukherjee trained in cancer medicine at the Dana Farber Cancer Institute of Harvard Medical School and was on the staff at the Massachusetts General Hospital. He has published articles and commentary in such journals as Nature, New England Journal of Medicine, Neuron and the Journal of Clinical Investigation and in publications such as the New York Times and the New Republic. His work was nominated for Best American Science Writing, 2000 (edited by James Gleick). He lives in Boston and New York with his wife, Sarah Sze, an artist, and with his daughter, Leela.

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Mukherjee, Siddhartha
ISBN 10: 0099584573 ISBN 13: 9780099584575
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Editorial: Vintage Publishing, United Kingdom (2017)
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Descripción Vintage Publishing, United Kingdom, 2017. Paperback. Estado de conservación: New. Language: English . Brand New Book. Selected as a Book of the Year by The New York Times, The Economist, Independent, Observer and Mail on Sunday THE NEW YORK TIMES NUMBER ONE BESTSELLER SHORTLISTED FOR THE WELLCOME BOOK PRIZE 2017 `Dramatic and precise. [A] thrilling and comprehensive account of what seems certain to be the most radical, controversial and, to borrow from the subtitle, intimate science of our time. He is a natural storyteller. A page-turner. Read this book and steel yourself for what comes next Bryan Appleyard, Sunday Times The Gene is the story of one of the most powerful and dangerous ideas in our history, from bestselling, prize-winning author Siddhartha Mukherjee. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history - the story of Mukherjee s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to read and write the human genome - unleashing the potential to change the fates and identities of our children. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856 where a monk stumbles on the idea of a `unit of heredity . It intersects with Darwin s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds - from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes. Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity - and a vision of both humanity s past and future. Nº de ref. de la librería LIB9780099584575

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Editorial: Vintage Publishing, United Kingdom (2017)
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Descripción Vintage Publishing, United Kingdom, 2017. Paperback. Estado de conservación: New. Language: English . Brand New Book. Selected as a Book of the Year by The New York Times, The Economist, Independent, Observer and Mail on Sunday THE NEW YORK TIMES NUMBER ONE BESTSELLER SHORTLISTED FOR THE WELLCOME BOOK PRIZE 2017 `Dramatic and precise. [A] thrilling and comprehensive account of what seems certain to be the most radical, controversial and, to borrow from the subtitle, intimate science of our time. He is a natural storyteller. A page-turner. Read this book and steel yourself for what comes next Bryan Appleyard, Sunday Times The Gene is the story of one of the most powerful and dangerous ideas in our history, from bestselling, prize-winning author Siddhartha Mukherjee. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history - the story of Mukherjee s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to read and write the human genome - unleashing the potential to change the fates and identities of our children. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856 where a monk stumbles on the idea of a `unit of heredity . It intersects with Darwin s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds - from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes. Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity - and a vision of both humanity s past and future. Nº de ref. de la librería LIB9780099584575

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Descripción Vintage, 2017. Estado de conservación: New. Gives us an account of the fundamental unit of heredity - and a vision of both humanity's past and future. In this book, the story begins in an obscure Augustinian abbey in Moravia in 1856 where a monk stumbles on the idea of a "Unit of heredity". It intersects with Darwin's theory of evolution, and collides with the horrors of Nazi eugenics. Num Pages: 608 pages. BIC Classification: JFMG; PDR; PDX; PDZ; PSAK; TCBG. Category: (G) General (US: Trade); (P) Professional & Vocational; (U) Tertiary Education (US: College). Dimension: 198 x 129 x 32. Weight in Grams: 452. . 2017. Paperback. . . . . . Nº de ref. de la librería V9780099584575

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Descripción Vintage. Estado de conservación: New. Gives us an account of the fundamental unit of heredity - and a vision of both humanity's past and future. In this book, the story begins in an obscure Augustinian abbey in Moravia in 1856 where a monk stumbles on the idea of a "Unit of heredity". It intersects with Darwin's theory of evolution, and collides with the horrors of Nazi eugenics. Num Pages: 608 pages. BIC Classification: JFMG; PDR; PDX; PDZ; PSAK; TCBG. Category: (G) General (US: Trade); (P) Professional & Vocational; (U) Tertiary Education (US: College). Dimension: 198 x 129 x 32. Weight in Grams: 452. . 2017. Paperback. . . . . Books ship from the US and Ireland. Nº de ref. de la librería V9780099584575

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Descripción Vintage, 2017. Estado de conservación: New. book. Nº de ref. de la librería ria9780099584575_rkm

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