Solid-Phase Synthesis: A Practical Guide - Tapa dura

"Prepublication praise for Solid-Phase Synthesis. . . Both Fernando Albericio and Steven Kates, as well as most of the authors of individual chapters, are well known to members of the synthetic peptide community and the information they provide can be considered authoritative and reliable. . .. While writing this piece I had occasion to look in the manuscript for answers to two specific questions and readily found both. I intend to keep a copy of this book on my desk for ready reference and I can recommend that every peptide chemist and many classical organic chemists do the same." ---from the Foreword by R. B. Merrifield, The Rockefeller University, New York, N.Y.

This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.